"Reaction Mechanics and Transition States"
- Description: In this lab we will consider the SN1 and SN2 reaction mechanism for nucleophilic substitution. By considering transition structures, intermediates and solvation effects we will determine which pathway is favored for the reactions involving CN- attack of bromomethane and t-butyl bromide.
Suggested level: Graduate/advanced undergraduate
Learning objectives: Learn how compute stable structures, reaction intermediates, and transition states; review concepts of enthalpy, entropy, and Gibbs free energy; learn how to incorporate solvent in calculations.